A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100.
نویسندگان
چکیده
A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.
منابع مشابه
New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron.
The nucleotide sequence of a plasmid-borne trimethoprim resistance gene from a commensal fecal Escherichia coli isolate revealed a new dihydrofolate reductase gene, dfrXV, which occurred as a gene cassette integrated in a site-specific manner in a class 1 integron. The new gene shows 84% nucleotide identity and the predicted protein shows 90% amino acid identity with dfrI and DHFR type I, respe...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 35 11 شماره
صفحات -
تاریخ انتشار 1991